ÓÄÊ 619:616.988
DOI 10.33861/2071-8020-2025-6-31-34
Original Empirical Research
Gomazkov D. V., Litvinov O. B.
Abstract. Despite the fact that the number of clinical trials of acute phase proteins (hereinafter, OFS) has increased significantly over the past decade, and most laboratories now offer basic OFS in their biochemical profiles, research on these proteins has not become widespread among veterinarians. Obtaining data on the level of acute phase proteins is a useful marker for detecting the presence or absence of inflammation in cats with various diseases, including infectious ones. Acute phase proteins can also be successfully measured in various biological fluids (exudate, urine, cerebrospinal fluid), which increases their diagnostic significance. Measuring these proteins can be extremely useful for cats with infectious peritonitis (hereinafter, FIP) and important. Understanding the possible benefits of acute phase proteins, additional research is needed, in particular, the use of acute phase proteins for therapy strategies and determining the duration of treatment with antimicrobials and modern antiviral drugs. In human medical practice, these protein markers of inflammation, which have great diagnostic value, are widely used. It would be desirable for these data to be studied in veterinary medicine to further verify the effectiveness of BOF in the diagnosis and control of treatment for a veterinarian in order to distinguish between cats with FIP and cats without FIP with a similar clinical picture. Repeated and consistent measurement of acute phase proteins is of particular importance, especially when evaluating the effectiveness of therapeutic tactics. BOF is more sensitive than the number of white blood cells for early detection of inflammation and assessment of early remission or recurrence of the disease.
Keywords: acute phase proteins, cats, infectious peritonitis, diagnostic marker, systemic inflammation, immunopathogenesis, differential diagnosis.
Author affiliation:
Litvinov Oleg B., D.Sc. in Veterinary Medicine, professor of the Department of Immunology and Biotechnology of the Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I. Skryabin; 23, Academician Skryabin st., Moscow, 109472.
Responsible for correspondence with the editorial board: Gomazkov Denis V., postgraduate student of the Department of Immunology and Biotechnology of the Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I. Skryabin; 23, Academician Skryabin st., Moscow, 109472; e-mail: denis.gomazkov@yandex.ru.
Authors’ Contribution:
Gomazkov D. V.: formal analysis, investigation, validation, visualization, writing – original draft preparation.
Litvinov O. B.: conceptualization, data curation, supervision, resources, writing – editing.
Conflict of Interest Statement: the authors declare no conflict of interest.
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