ÓÄÊ 631.95:637.5
DOI 10.33861/2071-8020-2025-6-9-11
Original Empirical Research
Miroshnichenko P.V., Danilchenko O.B.
Abstract. Mycotoxicoses and gastrointestinal diseases caused by opportunistic microflora cause a serious health problem for small cattle and cause significant economic damage to the livestock industry by reducing the quality of the products obtained. Traditionally used preventive measures, namely feed quality control and the use of antibiotics, have a number of disadvantages: the risk of developing resistance, environmental consequences, reduced value of livestock products, and economic damage. In connection with the above, there is an increasing need for natural and safe mycotoxin adsorbents capable of reducing the pathogenic load. The aim of the described study was to investigate the prophylactic efficacy of Klinocil for the prevention of mycotoxicoses and gastrointestinal diseases in small cattle caused by opportunistic microflora, as well as to assess its impact on animal health and productivity.
Materials and methods. The study was conducted at the Krasnodar Research Veterinary Institute and on livestock farms in the Krasnodar Territory. A laboratory assessment of the contamination level of feed used for small cattle with mold fungi and their producers was conducted. The ability of the studied agent to adsorb mycotoxins and its effect on opportunistic microflora present in the feed of livestock farms where the experiments were conducted were studied in vitro. The preventive effectiveness of the new agent was assessed when used in small horned cattle.
Results and discussion. The content of mycotoxins was determined in feed used in livestock farms. The ability of Klinocil to adsorb zearalenone and T-2 toxin was assessed in laboratory conditions, and its bactericidal activity was established. The effect of the studied agent on the biochemical parameters of sheep blood was studied and analyzed.
Conclusion. The results obtained during the studies allow us to conclude that the new drug Klinocil has bactericidal and adsorbent properties. It was found that in the experimental groups, the hematological parameters remained within the normal range, which confirms the prophylactic efficacy of Klinocil.
Keywords: T-2 toxin, zearalenone, small cattle, feed, intoxication, adsorption index, prevention of mycotoxicosis, opportunistic microflora.
Author affiliation:
Miroshnichenko Petr V., PhD., in Veterinary Medicine, leading scientific researcher, headof thedepartment ofepizootology, mycologyand veterinary sanitary expertise of the Krasnodar Research Centre for Zootechnics and Veterinary Medicine; 1, 1 Line st., Krasnodar, 350004, phone: 8-918-4470155; e-mail: mpetrvas@mail.ru.
Responsible for correspondence with the editorial board: Danilchenko Olesya B., Ph.D. in Biology, senior scientific researcher of departmentofepizootology, mycologyandveterinary sanitaryexpertiseof the Krasnodar Research Centrefor Zootechnics and Veterinary Medicine; 1, 1 Line st., Krasnodar, 350004, phone: 8-918-4521300; e-mail: danilchenkolesya@gmail.com.
Authors’ Contribution:
Miroshnichenko P.V.: conceptualization, investigation, writing -editing.
Danilchenko O.B.: investigation, visualization, validation, writingoriginal draft preparation.
Conflict of Interest Statement: the authors declare no conflict of interest.
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