ÓÄÊ 619.636.2.033
DOI 10.33861/2071-8020-2025-5-16-19
Original Empirical Research
Topuriya L. Yu., Lavrushina E. E., Gugushvili N. N., Topuriya G. M.
Abstract. In modern conditions of animal husbandry, to increase the productive potential of farm animals and poultry, the use of feed additives of various origins is widely used, which improve the digestibility of nutrients in the diet, reduce feed costs for the production of livestock products, improve the quality and safety of the products obtained. The range of feed additives on the domestic market is quite large and diverse. The most promising area of veterinary medicine and animal husbandry is the development, study and introduction of symbiotic microflora into production. Probiotics contain representatives of the normal microflora of the intestinal tract, have a positive effect on the macroorganism, normalize digestion, reduce morbidity in young animals, have immunostimulating activity, and are an alternative to the use of antimicrobial agents in livestock industries. The effect of different doses of the probiotic monosporin on the morphological composition of blood, natural resistance factors, cellular and humoral immunity of calves was studied. Three groups of day-old calves were formed. The young animals of the experimental groups received the probiotic in a dose of 4.0 ml and 6.0 ml once a day. It was found that the use of the drug contributes to an increase in the red blood cells of animals at the age of 6 months by 7.39-9.89%, hemoglobin - by 3.55-5.38%. An increase in the phagocytic properties of leukocytes is observed: phagocytic activity - by 5.54-6.26%, phagocytic index - by 9.22-11.27%. The indicators of lysozyme and bactericidal activity of blood serum improved, the number of immunocompetent cells increased. The number of circulating immune complexes in animals under the influence of the probiotic did not change.
Keywords: calves, probiotic, blood, immunity, natural resistance, formed elements.
Author affiliation:
Topuria Larisa Yu., D. Sc. in Biology, Professor, Professor of the Department of Veterinary and Sanitary Expertise and Pharmacology of the Orenburg State Agrarian University; 18, Chelyuskintsev st., Orenburg, Orenburg region, 460014; e-mail: golaso@rambler.ru.
Lavrushina Elena E., Ph.D. in Biology, Docent, Docent of the Department of Radiochemistry of the Dimitrovgrad Engineering and Technology Institute – a branch of the National Research Nuclear University MEPhI; 294, Kuibysheva st., Dimitrovgrad, Ulyanovsk region, 433511; e-mail: lav_e_e@mail.ru.
Gugushvili Nino N., D.Sc. in Biology, Professor, Professor of the Department of Microbiology, Epizootology and Virology of the Kuban State Agrarian University named after I. T. Trubilin; 13, Kalinina st., Krasnodar, 350044.
Responsible for correspondence with the editorial board: Topuria Gocha M., D. Sc. in Biology, Professor, Professor of the Department of Normal Physiology of the Orenburg State Medical University; 6, Sovetskaya st., Orenburg, Orenburg region, 460014; e-mail: golaso@rambler.ru.
Authors’ Contribution: the manuscript was written with the input of all authors. All authors approved the final version of the manuscript.
Conflict of Interest Statement: the authors declare no conflict of interest.
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