![](img/p.gif) |
УДК619:616.98:578.8212.63622828 Chernykh O.Yu., Mishchenko A.V., Mishchenko V.A., Gubeeva E.G., Papunidi K.Kh., ChernovA.N., Lysenko A.A., Shevchenko A.A., Shevkoplyas V.N., VatsaevSh.V. Summary. Changes at the cellular level are described in all organs and tissues during pathomorphological study of the large horned cattle with nodular dermatitis. The obtained by the authors data confirm the serious changes in the whole organism. The parenchymal organs and connective tissue, as well as the skin are involved in the pathological process. The greatest lesions are noted in the skin. The onset of edema in the dermis is associated with vascular thrombosis, which leads to coagulation necrosis of surrounding tissues. Fibrinoid necrosis of deep layers of the skin with violation of epithelialization in the focus, infiltration by polymorphic cells with a predominance of lymphocytes, decay of cells by the type of karyorexis are registered. Eosinophilic exudate was observed on the surface of the larynx and polymorphic cell infiltration of the laryngeal wall during the study of histological sections of the larynx. Authors also described fragmentary fibrinoid necrosis of artery walls, perivascular edema and infiltration of lymphocytes, leukocytes, histiocytes in the cardiac muscle. Interstitial small focal accumulations of lymphocytes, histiocytes in the stroma with swelling and homogenizing of fibrous structures eosinophilic clusters, interstitial hemorrhage, diffuse infiltration with lymphocytes in the wall of the stomach was also recorded. Infiltration of leukocytes, lymphocytes, disturbance of the structure of the villi in the form of homogenization and basophilic staining revealed in the small intestine; serous-purulent inflammation with fibrinoid necrosis of the walls of the vessels, focal emphysema and hemorrhages in the lungs; interstitial fibrinous-purulent infiltrates with focal fibrinoid necrosis of the stroma, necrosis of the epithelium of the convoluted tubules in the kidneys. The above mentioned morphological changes must be taken into account in confirming the diagnosis on nodular dermatitis in large horned cattle. Keywords: Lumpy skin disease, Ehrlich hematoxylin, skin, necrosis, microthrombi, heart, fibrinoid necrosis, kidney, tubular necrosis, edema, karyorexis, lungs, infiltration in alveoli. References: 1. Kodeks zdorovyya nazemnykh zhivotnykh MEB [OIE Terrestrial Animal Health Code]. - 2014. 2. Akulov A.V., Apatenko V.M., Arkhipov N.I. et. al. Kozhnaya bugorchatka. Patologoanatomicheskaya diagnostika virusnykh bolezney krupnogo rogatogo skota [Cutaneous tubercle. Pathological diagnostics of viral diseases of large horned cattle]. - Agropromizdat. - Moscow, 1987. - pp. 147-149. 3. Mishchenko A.V., Mishchenko V.A. Epizooticheskaya situatsiya po transgranichnym i ekonomicheski znachimym infektsionnym boleznyam krupnogo rogatogo skota v Rossii v 2013 godu [Epizootic situation on transboundary and economically significant infectious diseases of large horned cattle in Russia in 2013]. - Kazan, 2014. 4. Mishchenko V.A. Sovremennaya situatsiya po infektsionnym boleznyam krupnogo rogatogo skota v Rossiyskoy Federatsii [Modern situation on infectious diseases of large horned cattle in the Russian Federation]. - Moscow, 2015. 5. Mishchenko A.V., Mishchenko V.A. Epizooticheskaya situatsiya po transgranichnym i ekonomicheski znachimym infektsionnym boleznyam krupnogo rogatogo skota v Rossii v 2013-2014 godakh [Epizootic situation on transboundary and economically significant infectious diseases of large horned cattle in Russia in 2013-2014]. - Saint-Petersburg, 2014. - pp. 165-167. 6. Syurin V.N., Samuylenko A.Ya., Solovyev B.V., Fomina N.V. Nodulyarnyy dermatit. Virusnyye bolezni zhivotnykh [Lumpy skin disease. Viral diseases of animals]. - VNITIBP. - Moscow, 1998. - pp. 747-750. 7. Samuylenko A. YA., Solovyev B.V., Nepoklonov Ye.A., Voronin Ye. S. Nodulyarnyy dermatit. Infektsionnaya patologiya zhivotnykh [Lumpy skin disease. Infectious pathology of animals]. - Akademkniga. - Moscow, 2006 (1). - 782786. 8. Kosareva O.A., Kukushkina M.S., Konstantinov A.V. et. al. Nodulyarnyy dermatit (bugorchatka), klinicheskiye priznaki pri eksperimentalnom zarazhenii krupnogo rogatogo skota [Lumpy skin disease, clinical features during experimental infection of large horned cattle]. - VNlIZZh. - Vladimir, 2010 (8). - pp. 73-83. 9. Arkhipov N.I., Chevelev S.F., Bragin G.I. et. al. Nodulyarnyy dermatit. Patologoanatomicheskaya diagnostika virusnykh infektsiy zhivotnykh [Nodular dermatitis. Pathoanatomical diagnosis of viral infections of animals]. - Kolos. - Moscow, 1984. - pp. 69-72. 10. Makarov V.V., Grubyy V.A., Gruzdev K.N., Sukharev O.I. Spisok MEB i transgranichnyye infektsii zhivotnykh [OIE list and transboundary animal infections]. - VNIIZZH. - Vladimir, 2012. - pp. 76-79. 11-21. Vide supra. Author affiliation: Mishchenko Alexey V., Ph.D. in Veterinary Medicine, vice director for research and monitoring of the Federal Centre for Animal Health; mcrd. Yurievets, Vladimir, 600901; phone: 8-4922-261765 (ext. 21-55); e-mail: mischenko@arriah.ru. Mishchenko Vladimir A., D. Sc. in Veterinary Medicine, professor, chief scientific researcher of the laboratory of epidemiology and monitoring of the Federal Centre for Animal Health; mcrd. Yurievets, Vladimir, 600901; phone: 8-4922-261765 (ext. 21-55); e-mail: mischenko@arriah.ru. Gubeeva Elena G., Ph.D. in Medicine, leading scientific researcher of the Federal Center of Toxicological, Radiation and Biological Safety; 2, Scientific town, Kazan, Republic of Tatarstan, 420075; e-mail: vetvrach-vnivi@mail.ru. Papunidi Konstantin Kh., Ds.C. in Veterinary Medicine, professor, Deputy Director for Science and Toxicological safety of the Federal Center of Toxicological, Radiation and Biological Safety; 2, Scientific town, Kazan, Republic of Tatarstan, 420075; e-mail: vetvrach-vnivi@mail.ru. Chernov Albert N., Ds.C. in Biology, Deputy Director for Science and Biological safety of the Federal Center of Toxicological, Radiation and Biological Safety; 2, Scientific town, Kazan, Republic of Tatarstan, 420075; e-mail: rt-kazan@mail.ru. Lysenko Aleksandr A., D.Sc. in Veterinary Medicine, professor of the department of therapy and pharmacology of the Kuban State Agrarian University named after I.T. Trubilin; 13, Kalinina st., Krasnodar, 350044; phone: 8-861-221-58-20; e-mail: vet.kubgau@mail.ru. Shevchenko Aleksandr A., D.Sc. in Veterinary Medicine, professor, Academician of the Russian Academy of Natural Sciences and International Academy of Pedagogical Education, Head of the department of microbiology, virology and epizootology of the Kuban State Agrarian University named after I.T. Trubilin; 13, Kalinina st., Krasnodar, 350044; phone: 8-861-2215820; e-mail: shevchenko_aa@rambler. ru.. Shevkoplyas Vladimir N., D.Sc. in Veterinary Medicine, professor, director of the Veterinary Departament of the Ministry of Agriculture of the Russian Federation; 1/11, Orlikov per., Moscow, 107139; phone: 8-499-9754347; e-mail: shevkoplyasvn@gmail.com. Vatsaev Shakhab V., Ph.D. in Veterinary Medicine, docent of the department of Veterinary Medicine of the Chechen State University; 32, Sheripova st., Grozny, 364907; e-mail: vac-60@mail.ru. Responsible for correspondence with the editorial board: Chernykh Oleg Yu., D.Sc. in Veterinary Medicine, director of the Kropotkin regional veterinary laboratory; 303, Krasnoarmeyskaya st., Kropotkin, 352380; phone: 8-86138-62314; e-mail: gukkvl50@kubanvet.ru.
|
![](img/p.gif) |